Inhibition of Cell Adhesion by an Anti-cadherin 11 Antibody Prevents Bone Metastasis
نویسندگان
چکیده
From the Departments of Translational Molecular Pathology, Genitourinary Medical Oncology, Orthopaedic Oncology, Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Department of Medicine, Baylor College of Medicine, Houston, Texas Department of Pharmacy at National Taiwan University Hospital, Taipei, Taiwan Abnova Corporation, Taiwan. * Authors contributed equally
منابع مشابه
Bone Metastasis Inhibition of Cell Adhesion by a Cadherin-11 Antibody Thwarts
Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells t...
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Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells t...
متن کاملInhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
UNLABELLED Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate ca...
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Background: E-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. Loss of the adhesive function of E-cadherin seems to promote invasive and metastatic properties of neoplastic cells. Objectives: The present study is a retrospective study aiming to evaluate the loss of E-cadher...
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